UCSF Dermatology Grand Rounds 29 July 2026

Grand Rounds and Patient Cases

ZOOM 

Developing Risk Stratification Models for Patients with Cutaneous Squamous Cell Carcinoma.

Marlies Wakkee, MD, PhD, Professor in dermatology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands

Objectives:

1. Describe current strategies for identifying patients with cutaneous squamous cell carcinoma (cSCC) at high risk of metastasis, including the strengths and limitations of existing staging systems.

2. Understand how population-based datasets and nested case–control study designs can be used to develop and validate risk prediction models for rare outcomes such as metastatic cSCC.

3. Compare traditional staging approaches with absolute risk prediction models and discuss how clinicopathological and gene-expression biomarkers can be integrated to improve risk stratification and personalized patient management.

Disclosures: Marlies Wakkee, MD, PhD, has disclosed that she has received speaker fees and advisory board honoraria from Regeneron and Sun Pharma and her research group has received research funding from Regeneron.

Moderator Disclosures: Garrett Patrick, MD, PhD has no relationships to disclose.

Planner Disclosures: Hunter Shain, PhD has disclosed that he has an industry sponsored research
agreement with Kenview and Skyline Dx. Kelly Cordoro, MD and Katrina Abuabara, MD have stated that they have no financial relationships to disclose.