Stem Cell Genome Editing Series

Join us for our Stem Cell Genome Editing Series, showcasing cutting-edge advances in genome editing for stem cell biology and therapeutic development. The series reflects the Center for Genome Surgery’s mission to address critical challenges in gene editing and aligns with the UCSF Broad Stem Cell Center’s vision to Discover, Engineer, Heal. At our Jan 27 session, we will hear from speaker Nadav Ahituv, PhD, who will present “Targeting gene regulatory elements for therapeutic benefits."

By targeting regulatory elements via CRISPR activation (CRISPRa), we show that they can be used to rescue a variety of haploinsufficient diseases (having ~50% dosage reduction due to having only one functional allele). In addition, utilizing CRISPRa to engineer adipocytes and adipose organoids to outcompete tumors for nutrients, we show that they can be used as a novel cancer therapy, termed Adipose Manipulation Transplantation (AMT).

Speaker Lineup
Jan 27 | Nadav Ahituv “Targeting gene regulatory elements for therapeutic benefits”
Feb 10 | Greg Mohl "High-throughput platforms for gene editing and delivery optimization"
Feb 24 | Serine Avagyan "Multiplex mosaic CRISPR-cas9 mutagenesis in vivo"
March 10 | Alex Marson "Decoding and Reprogramming Human T Cell Circuits with CRISPR"
March 24 | Peter Bruno "Synthetic biology to enable antigen presentation screening systems"
April 28 | James Gardner TBA
May 12 | Seth Shipman TBA

UCSF welcomes all participants to our events. If you need a reasonable accommodation to participate in this event because of a disability, please contact [email protected] as soon as possible.