Edward and Pearl Fein Memory and Aging Center Grand Rounds

Midlife Autonomic Reconfiguration and Alzheimer's Disease: Physiological Pathways Linking Parasympathetic Decline and Sympathetic Hyperactivity to Disease Risk

Mara Mather, PhD
Professor of Gerontology, Psychology, and Biomedical Engineering
University of Southern California

Learning Objectives

• Explain how parasympathetic and sympathetic activity levels change during young and mid-adulthood.
• Describe evidence for links between parasympathetic/sympathetic activity and amyloid-β and tau pathways.
• Describe how randomized clinical trials involving slow-paced breathing affected plasma amyloid-β levels.

Disclosures

• Planners: Bruce L. Miller, MD; Howard J. Rosen, MD; Anil Vora; and Laura Wise have stated they have no relationships to disclose.
• Speaker: Mara Mather, PhD, has stated she has no relationships to disclose.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Edward and Pearl Fein Memory and Aging Center Grand Rounds sessions offered from January 1, 2026, through December 31, 2026. (1 credit per each 1-hour grand rounds session throughout the year).

Virtual attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.