Edward and Pearl Fein Memory and Aging Center Grand Rounds

X Marks the Spot: ‌Longevity and Brain Resilience

Dena Dubal, MD, PhD
Professor of Neurology
David A. Coulter Endowed Chair in Aging and Neurodegenerative Disease
UCSF Weill Institute for Neurosciences

Learning Objectives

• Describe current known sex differences in typical cognitive aging and Alzheimer's disease.
• Understand how the X chromosome influences neural functions in aging.

Disclosures

• Planners: Bruce L. Miller, MD; Howard J. Rosen, MD; Anil Vora; and Laura Wise have stated they have no relationships to disclose.
• Speaker: Dena Dubal, MD, PhD, is a scientific co-founder of Jocasta Neurosciences and has served as a consultant for Unity Biotechnology, SV Health Investors, and Jocasta Neurosciences. She has received funding from the National Institutes of Health (NIH), the American Federation for Aging Research (AFAR), and the Simons Foundation. Dr. Dubal holds intellectual property and discoveries assigned through the UC Regents, including patents and pending applications: Methods and Compositions for Improved Cognition, UCSF, Awarded 2019 (Patent number: 10864256): Patents: 12,239,694 (2025); 11,738,070 (2023); 10,864,256 (2020); 10,632,180 (2020); 10,300,117 (2019); Related Applications: US 2025/0161418; US 2024/0108698; US 2021/0069305; US 2020/0230214; US 2018/0256688; US 2018/0015151; Platelet Factors and Cognitive Improvement, UCSF, Filed; U.S. Application: US 2023/0181691; Use of Downstream Factors in the Klotho Pathway to Assess Klotho Activity, UCSF, Filed; U.S. Application: US 2023/0123357; X Chromosome Gene Products That Improve Cognition, UCSF Filed 63/766,693. Dr. Dubal also serves in leadership roles at JAMA Neurology and on the boards of the Glenn Medical Foundation and Weill Neurohub.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Credit is inclusive of all Edward and Pearl Fein Memory and Aging Center Grand Rounds sessions offered from January 1, 2026, through December 31, 2026. (1 credit per each 1-hour grand rounds session throughout the year).

Virtual attendees must register for this event. Grand Rounds presentations are for educational purposes and intended for a professional audience with a terminal degree. This activity is not commercially supported.