Memory and Aging Center Grand Rounds

The Zinc finger protein Zfp106 functions as an RNA-binding protein and plays multiple roles in neurodegeneration

Brian Black, PhD
Professor, Cardiovascular Research Institute
Department of Biochemistry and Biophysics
University of California, San Francisco

Objectives

Attendees will:

• Learn about the function of Zfp106 as an RNA-binding protein;
• Understand G-quadruplex structures in RNA and the possible roles in neuroprotection;
• Learn how Zfp106 loss-of-function results in an ALS-like neurodegenerative phenotype in mice;
• Learn how Zfp106 interacts with GGGGCC expansions, such as those that cause C9orf72 ALS/FTD.

Disclosures

• Planners: Lawren VandeVrede, MD, PhD; Bruce L. Miller, MD; Howard J. Rosen, MD; and Eleanor O’Brien have stated they have no relationships to disclose.
• Speaker: Dr. Black will disclose any relevant relationships at the beginning of his talk.

Accreditation: The University of California, San Francisco (UCSF) School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation: UCSF designates this live activity for a maximum of 22 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The above credit is inclusive of all Memory and Aging Center Grand Rounds sessions offered July 2018 through December 2018. (1 credit per each 1-hour grand rounds session throughout the year).

NOTE: You must sign in to qualify for CME Credit

Grand Rounds presentations are for educational purposes and intended for a professional audience. This activity is not commercially supported.