Molecular Medicine Faculty

MMP faculty have made a commitment to mentoring MMP Students and Residents, and participating in Molecular Medicine Case Conference. MMP faculty have appointments in many departments across the schools of Medicine, Dentistry, Pharmacy, and the Graduate Division at UCSF, and work in laboratories at Parnassus Heights, Mission Bay, Mount Zion, San Francisco General Hospital, and the Veterans Administration.

Research Interests
Professor Chair, Pathology
cell cycle regulation, stem cell biology, cell signaling, muscle biology, myocardial regeneration, heart failure website


Nadav Ahituv, PhDAsst. Professor Biopharmaceutical Science and IHGhuman genetics, genomics, gene regulation, limb malformations, obesity, pharmacogenomics, enhancer, mouse models, zebrafis website
Mark S. Anderson, MD, PhDAssistant Professor Diabetesautoimmunity, immune tolerance, thymic selection website
Associate Professor, Anesthesia/Perioperative Care
cellular signaling mechanisms that control barrier function, biology and physiology of xenobiotic transport, translational therapies based on modulation of the BBB website
Anna Bakardjiev, MDAssociate Professor, Pediatricshost-pathogen interactions at the maternal-fetal interface website
Sergio E. Baranzini, PhDAdj. Asst. Professor, Neurology
Gladstone Institute
systems biology, multiple sclerosis genetics/genomics, gene expression/bioinformatics, experimental neuroimmunology, mathematical/statistical modeling website
Diane L. Barber, PhDProfessor and Vice Chair, Cell and Tissue Biologycell migration, cancer, metastasis, turmorigenesis, actin cytoskeleton, intracellular pH, epithelial to mesenchymal transition (EMT) website
Professor & Chair, Department of Anatomy
the neurological basis of pain and its control website
Michael S. Beattie, PhDProfessor, Neurological Surgeryneural injury and repair, regeneration, spinal cord injury, apoptosis, stem cell transplantation, recovery of neurological function, cell death, de- and remyelination website
Daniel D. Bikle, MD, PhD
Professor, Endocrinevitamin D and calcium regulation of keratinocyte differentiation; role of IGF-I in the anabolic response of bone to mechanical load and parathyroid hormone website
Michael Brainard, PhD
Professor of Physiology and Psychiatry
neural-genetic systems of motor skill learning website
Ben Braun, MD, PhD
Assistant Professor, Department of Pediatrics, Hemology/Oncology
ras signaling in cancer stem cells website
Trevor Burt, MD
Assistant Professor, Pediatrics
Tcell development and function in the fetus and newborn website
Jeffrey Bush, PhD
Assistant Professor, Dept. of Cell & Tissue Biology
signaling control of craniofacial development and congenital disease website
Harold A. Chapman, MDProfessor, Medicine and Pulmonaryinterstitial lung disease and pulmonary fibrosis, integrin signaling in lung cancer, epithelial mesenchymal transition pathways of TGFβ1 signaling website
Ben Cheyette, MD, PhDAssociate Professot, Psychiatrysignaling, cytoskeletal dynamics and cell adhesion website
Shweta Choudhry, PhD
Asst. Adjunct Professor, Lung Biologyasthma, COPD, interstitial lung diseases, diabetes, cardiovascular disease, metabolic, syndrome, complex diseases, population genetics, molecular genetics, pharmacogenetics, admixture, admixture mapping, population stratification, understudied populations, race/ethnicity, candidate gene, studies, genome-wide association studies, gene-environment interactions, gene-gene interaction, pathway analysis
Céline I. Colnot, Ph.DAsst. Professor, Orthopaedic Surgerycartilage and Bone Biology, Developmental Biology, Skeletal Repair and Regeneration, Cellular and Molecular Biology, Skeletal Stem Cells, In vivo Cell Lineage Analysis, Angiogenesis, Inflammation, Extracellular Matrix Remodeling website
Bruce R. Conklin, MDSr. Investigator Gladstone Institute of Cardiovascular Disease, Professor, UCSF Department of Medicine, Division of Medical GeneticsSignaling, Hormones, G protein coupled receptors, stem cells, cardiac, bioinformatics website
Michael Salvatore Conte, MDChief, Vascular Surgeryvascular injury, vein bypass graft, angioplasty, gene therapy, smooth muscle cells website
Shaun Coughlin, MD, PhD
Professor and Director, UCSF Cardiovascular Research Institute (CVRI)
signaling mechanisms in cardiovascular biology and disease website
Lindsey Criswell, MD, MPH
Chief, Division of Rheumatology
genetics and epidemiology of human autoimmune disease website
Heike E. Daldrup-Link, MD, PhDAssociate Professor, Radiology and Pediatricsimaging, molecular imaging, cellular imaging, cell tracking radiology website
BMS website


Jayanta Debnath, MDAssistant Professor, Pathologyautophagy, apoptosis, oncogenes, breast cancer, three-dimensional culture, epithelial cancersextracellular matrix, integrins, ubiquitin-like molecules website
Rahul Deo, MD, PhD
Assistant Professor, Division of Cardiology
Computational and cellular approaches to metabolic disease website
Allison Doupe, MD, PhD
Professor of Psychiatry and Physiology
Director, UCSF Center for Integrative Neuroscience
Structural Characterization of Molecular Switches in Signal Transduction website
Robert Edwards, MD
Professor, Neurology
The Molecular Basis of Neurotransmitter Release and Its Role in Synaptic Physiology, Behavior and Disease website
Joanne Engel, MD, PhD
Chief, Division of Infectious Diseases
bacterial host-Cell Interactions website
David Erle, MDProfessor, Medicineasthma, immunology, genomics, gene regulation, DNA microarrays, micro-RNA website
Margaret Feeney, MD, MMSc
Associate Professor, Division of Experimental Medicine
Immunopathogenesis of HIV and malaria in childhood website
Donna M. Ferriero, MDProfessor, Neurology and Pediatricsbrain development, newborn brain injury, excitotoxicity, hypoxia inducible genes, neuroprotection website
Howard L. Fields, MD, PhD
Professor, Neurology and Physiologyalcoholism and drug addiction, neuroscience of motivation website
Susan Fisher, PhD
Professor, Cell Tissue and Biology
Placental development in normal and abnormal pregnancies, the biology of human embryos and human embryonic stem cells, biological mass spectrometry website
James A. Frank, MD
Associate Professor, Medicineacute lung injury, acute respiratory distress syndrome, pulmonary edema, ion transport, permeability, tight junction, alveolar epithelium, pulmonary fibrosis, sepsis, lung cancer website
Fen-Biao Gao, PhD
Associate Professor, Neurologyfrontotemporal dementia, neurodegeneration, microRNAs website
Michael S. German, MD
Professor, Diabetes Centerdiabetes mellitus, insulin, carbohydrate metabolism, pancreas, islets of Langerhans, beta-cells, developmental, biology, stem cell, biology, regeneration, gene expression, transcription factors, microRNA, genomics
Linda Giudice, MD, PhD, MScProfessor and Ob/Gyn Chair, Ob/Gyn and Reproductive Scienceshuman reproduction, functional genomics, steroid hormone action, endocrine disruptors, mucosal immunity, ovarian cancer, stem, cells, translational science website


Andrei Goga, MD, PhD
Associate Professor, Dept. of Cell & Tissue Biology
Oncogene Signaling Pathways that Regulate the Cell Cycle, microRNAs and Metabolism website
Su Guo, PhD
Associate Professor, Biopharmaceutical Sciencesneuroscience, developmental biology, stem cells, Parkinson's disease, genetics, dopamine biology, behavior website
Nalin Gupta, MD, PhD


Associate Professor, Neurological Surgery and Pediatricspediatric brain tumors, macrophage infiltration, drug delivery, mouse models website


Jiang He, PhDAssistant Professor, Radiologymolecular imaging, drug targeting and drug delivery, nanotechnology, peptide, antibody discovery; radiotracer, radiopharmaceutics, radiotherapy, nuclear imaging; angiogenesis, breast cancer, prostate cancer, pancreatic cancer website
Judith Hellman, MD
Associate Professor, Department of Anesthesia and Perioperative Care
Role of Innate Immune Pathways in Sepsis and Critical Illness website
Michelle Hermiston, MD, PhD
Assistant Professor, Pediatricssignal transduction, phosphatase, mouse models of benign and malignant hematologic disease, leukemia, lymphoma, phospho-flow cytometry, macrophage activation syndrome, lupus, autoimmunity, tolerance, dendritic cell, B cell, homeostasis website


Edward Hsiao, MD, PhD
Assistant Professor, Division of Endocrinology and Metabolism
Institute for Human Genetics
Hormonal and genetic regulation of human skeletal disease website
Katherine M. Hyland, PhD
Associate Professor, Biochemistry and BiophysicsProfessional Courses Co-Director website
Ajay N. Jain, PhD


Professor, Cancer Research Institutemolecular docking, molecular similarity, ligand-based activity modeling, organism-scale multi-target prediction of biological activity, and computational approaches to rationalizing pharmacology website
Ella Fung Jones, PhD


Assistant Professor, Radiologymolecular imaging, optical imaging, multi-modality imaging, contrast agents development for X-ray and optical imaging, in vivo monitoring of protease activities, disease progression, drug dosage response, targeted imaging website
Ophir David Klein, MD, PhD
Assistant Professor, Orofacial Surgerystem cells, developmental biology, regenerative medicine, craniofacial biology, bone biology website
Jane Koehler, MD
Professor, Medicine
Pathogenic Interactions Between the Hemotrophic Bacterium Bartonella and Mammalian Host Cells website
Scott Kogan, MDAssociate Professor, Laboratory Medicineleukemia, hematopoiesis, cancer stem cells, carcinogenesis website
Arnold R. Kriegstein, MD, PhDDirector, Institute for Regeneration Medicinecortical development, neural stem cells, neural progenitor cells, neurogenesis, radial glia, neuronal migration, developmental neurobiology, neurophysiology website
Deanna L. Kroetz, PhD
Professor, Biopharmaceutical Sciencespharmacogenetics, drug netabolism, drug transporters, renal cytochrome P450 eicosanoid
Jennifer LaVail, PhDProfessor, Anatomy and Ophthalmologyneurobiology, virology, herpetic infections of the brain, axonal transport website
Patricia A. Leake, PhD
Professor, Otolaryngology - Head and Neck Surgerycochlear implants, auditory system development, plasticity, neurotrophins website
Andrew D. Leavitt, MD
Professor, Laboratory Medicine and Medicine
Medical Director, Adult Blood and Marrow Transplant Laboratory
human embryonic stem cells, hematopoietic stem cells, thrombopoietin/MPL signaling website
Randall J. Lee, MD, PhD
Professor, Cardiology, Section of Electrophysiologytissue engineering, myocardial regeneration, stem cells, antibodies website
Jay A. Levy, MDProfessor, Hematology/OncologyHIVAIDS, immunology, cell biology website
Long-Cheng Li, MD
Assistant Professor, UrologyRNA activation, gene regulation, small RNA and cancer website
Daniel A. Lim, MD, PhDAsst. Professor, Neurosurgerystem cells, adult neurogenesis, chromatin remodeling, epigenetics, cell transplantation, gene therapy, stereotactic neurosurgery, MRI-guided neurosurgery, neurodegenerative disease, Parkinson's disease, demyelinating diseases website
Mignon Loh, MD
Professor, Pediatrics
pediatric leukemia website
Daniel Lowenstein, MD
Professor, Neurology
epilepsy website
Tippi C. MacKenzie, MDAssistant Professor of Surgerystem cell transplantation, tolerance induction, fetal and neonatal immunity, fetal therapy website
Sharmila Majumdar, PhDProfessor and Vice Chair, Radiologyradiology, magnetic resonance imaging, image processing,computer-assisted, osteoporosis, osteoarthritis, osteoarthritis, knee, osteoarthritis, hip, imaging, bioengineering, cartilage, bone, inter-vertebral disc, musculoskeletal website
Emin Maltepe, MD, PhD
Assistant Professor, Pediatrics
regulation of Cell Fate by Oxygen and Mitochondria website
Assistant Professor, Orthopaedic Surgery
cranioacial development, structural birth defects, Shh, Fgf, Bmp, Wnt, neural crest, skeletal repair, stem cell therapy, trauma website
Marta Margeta, MD, PhDAssistant Professor, PathologyMetabolism, Excitability, and Neurologic Disease website
Carol Anne Mathews, MDAssociate Professor, Psychiatrygenetics, psychopathology, phenomenology, endophenotypes, psychiatric disorders of childhood, genetic epidemiology website
Mehrdad Matloubian, MD, PhD
Assistant Professor, Rheumatology
Lymphocyte Migration and Autoimmune Disease website
Michael A. Matthay, MDProfessor, Medicine and Anesthesiamesenchymal stem cells, lung fluid balance, acute lung injury, transport of salt, water and protein by the pulmonary epithelium website
Michael McCune, MD, PhD
Professor & Chief, Division of Experimental Medicine
Pathogenic Mechanisms, Treatment, and Prevention of HIV Disease website
Martin McMahon, PhDProfessor, Cancer Research InstituteRAF kinases; MAP kinase signaling; mouse models of human cancer; Cell cycle regulation; apoptosis; experimental therapeutics website
Michael T. McManus, PhDAssistant Professor, Diabetes CenterRNA interference, microRNAs, development, genetics, mouse models, noncoding RNAs website
Patrick S. McQuillen, MD
Assoc. Professor, Pediatrics Critical Caredevelopmental neuroscience, early hypoxic ischemic brain injury, selective vulnerability, plasticity, repair, regeneration, visual system, congenital heart disease, magnetic resonance imaging, neurodevelopmental, outcome, neuroprotection website
Robert O. Messing, MDProfessor, Neurologysubstance abuse, anxiety, pain, neuronal signal transduction, protein, kinase C, GABAA receptor, corticotrophin releasing hormone, neuropeptide Y, voltage-gated calcium channels, gene targeting, RNA interference, electrophysiology, behavioral pharmacology website
Theodore Miclau, MDProfessor, Orthopaedic Surgeryfracture, repair, molecular and cellular events, inflammation, angiogenesis, bone, and cartilage website
Barbara Moscicki, MD
Professor, Pediatrics
adolescent medicine, human papillomavirus (HPV) and cervical cancer website
Robert A. Nissenson, PhDProfessor, Medicine and Physiologycontrol of bone mass by G protein signaling in osteoblasts; molecular determinants of osteoblast differentiation; role of G protein signaling in mesenchymal stem cell fate decisions; interplay between the anabolic effects of parathyroid hormone and canonical Wnt signaling in osteoblasts website
Douglas F. Nixon, MD, PhDProfessor, MedicineHIV, immunity, T cells, endogenous retroelements, HTLV-1, mycobacterium tuberculosis, NK, NKT website
Linda J. Noble, PhD
Professor, Neurological Surgerymatrix metalloproteinases, oxidative stress, CNS trauma website
Suzanne Noble, MD, PhD
Assistant Professor, Infectious Disease
Biology of Candida albicans, a Unique Fungal Commensal-Pathogen of Humans website
Robert Nussbaum, MD
Professor, Medicine and Genetics
human molecular genetics, parkinson's disease, mouse models website
Scott Oakes, MD
Assistant Professor, Pathologybiochemistry of apoptosis, BCL-2 family, endoplasmic reticulum stress, myeloma, neurodegenerative disease website


Jorge R. Oksenberg, PhDProfessor, Neurologybiochemistry of apoptosis, BCL-2 family, endoplasmic reticulum stress, myeloma, neurodegenerative disease
Joel M. Palefsky, MD
Professor, Laboratory Medicine and Medicinehuman papillomavirus, human immunodeficiency virus, Epstein Barr virus, anogenital cancer, anogenital intraepithelial neoplasia website


Professor, Medicine, Microbiolology and Immunologyacquired and congenital immunodeficiencies, HIV/AIDS, immunotherapy of cancer, models of autoimmunity: transcription of MHC class II genes, antigen processing and presentation; replication of HIV, latency, mechanism of action of viral accessory genes; control of elongation of transcription in health and disease; global health website
Samuel J. Pleasure, MD, PhD
Associate Professor, Neurologybrain development; dentate gyrus; migration; Wnts; chemokines; retinoic, acid; meninges website
Louis J. Ptácek, MD
Professor, Neurologyepisodic disorders, epilepsy, migraine, circadian rhythm genetics, pathophysiology, animal modeling, human genetics website
Jennifer M. Puck, MDProfessor, Immunologyprimary immunodeficiency (PID), translational research, mouse models, newborn screening, immunology, genetics, gene therapy, severe combined immunodeficiency (SCID), autoimmune lymphoproliferative, syndrome (ALPS), hyper-IgE syndrome, lymphocyte development website
Katherine A. Rauen, MD, PhDAssociate Professor, Pediatrics Geneticsarray CGH, cardio-facio-cutaneous syndrome, cancer genomics, cancer syndromes, Costello syndrome, constitutional chromosome aberrations, cytogenetics, congenital abnormalities, genetic medicine, medical education, neurofibromatosis 1, Noonan syndrome, prenatal genetics, Ras/MAPK pathway website
Associate Professor, Biochemistry & Biophysics
Hedgehog cilia Wnt basal cell cancer carcinoma stem cell centriole centrosome Smoothened Tectonic Tctn1 Tctn2 Tctn3 transition zone Meckel syndrome website
Dorit Ron, PhD
Associate Professor, Neurologymolecular neurobiology of addiction, signal transduction website
Philip J. Rosenthal, MD
Professor, Infectious Diseasesmalaria, Plasmodium, parasitology, drug resistance, Africa, protease website
David Rowitch, MD, PhD
Professor of Pediatrics and Neurological Surgery, Chief of Neonatology
Overlapping Mechanisms in CNS Development and Disease website
John Rubenstein, MD, PhD
Professor, Department of Psychiatry
Genetic Regulation of Regional Specification and Differentiation in the Forebrain website
Srinath Sanda, MD
Assistant Adjunct Professor, Pediatrics
Diabetes, Immunology website
Mark A. Schumacher, MD, PhD
Associate Professor, AnesthesiaTRPV1, VR1, capsaicin receptor, splice variant, NGF, promoter, nociceptor, pain, transcription factors website
Nirao Shah, MD, PhD
Associate Professor, Anatomy
Neural control of sexually dimorphic behaviors website
Kevin S. Shannon, MD
Professor, Pediatrics, Hematology and Oncologymyeloid leukemia, mouse models, Ras, targeted therapeutics
Robin Mark Shaw, MD, PhD
Assistant Professor, Medicine and Cardiologycardiac electrophysiology, ion channels, membrane protein,trafficking, congestive heart failure, arrythmia, sudden cardiac, death, microRNA, TIRF microscopy website
Dean Sheppard, MDProfessor, Medicine, Lungmolecular bases of common lung diseases, in vivo, biology of integrins website
Elliott. H. Sherr, MD, PhDAssistant Professor, Neurologyautism, epilepsy, cognitive disability, genetics, brain development, diffusion tensor imaging, corpus callosum website
Assistant Professor, Division of Medical Genetics
Department of Pediatrics
Genomic Determinants in Human Developmental Disorders website
Anita Sil, MD, PhD

Assoc. Professor, Department of Microbiology & Immunology

Regulation of cell shape and virulence by temperature in the fungal pathogen Histoplasma capsulatum website
Professor, Cardiologydrug discovery, adrenergic receptors, knockout and transgenic mouse models, human heart tissue bank, heart and vascular cell culture (human, mouse, rat), cardiovascular molecular and cellular biology and physiology, brain ischemia, GPCR signaling, heart disease, heart failure, cardiomyopathy, heart transplantion, Neurological disease, traumatic brain injury website
Anne Slavotinek, MD, PhD
Associate Professor, Clinical Pediatrics Geneticsbirth defects, malformations, multiple congenital anomaly syndromes, congenital diaphragmatic hernia, anophthalmia, genome sequencing, microarrays, in-situ hybridization, expression studies, morpholino studies website
Vikaas Sohal, MD, PhD
Assistant Professor, Psychiatry
Information Processing in Cortical Microcircuits: Optogenetic Tools and Implications for Psychiatric Disease website
Matthew L. Springer, PhD
Associate Professor, Cardiologyangiogenesis, cardiac function, endothelial function, bone marrow cell therapy, gene therapy, endothelial progenitor cells, flavanols, second hand cigarette smoke website
Deepak Srivastava, MDDirector, Gladstone Institute Cardiovascular DiseasemicroRNA, cardiac development, differentiation website
Matthew State, MD, PhD
Chair, Department of Psychiatry; and Director of Langley Porter Psychiatric Institute
Autism spectrum disorders, genetics of autism, genetics and genomics of Tourette Syndrome website
Raymond A. Swanson, MD
Professor, Neurologyneuroscience, inflammation, mitochondria, oxidative stress, stroke, Parkinson's disease, DNA damage website
Larry Tecott, MD, PhD
Professor, Psychiatry
molecular genetics of serotonin system regulation of behavior website
Christian Vaisse, MD. PhD
Associate Professor, Diabetes Research Centerobesity, diabetes, human genetics, neural regulation of energy homeostasis, hypothalamus website
Zinaida S. Vexler, PhD
Associate Professor, Neurologystroke, neurodegeneration, inflammation, chemokine, protection, repair, neonate, MRI website
Susan Voglmaier, MD, PhD
Assistant Professor, Psychiatry
Vesicle Trafficking and Neurotransmitter Release website
Mark Von Zastrow. MD, PhDProfessor, Psychiatry
Linking Cell Signaling and Membrane Traffic website


Associate Professor, Lung Biology Centerlung development, lung vascular development, lung alveolar development, asthma, lung cancer, COPD, respiratory diseases, global health website
Ethan Weiss, MD
Assistant Proessor, CVRI
Hormonal regulation of energy metabolism/ Novel mechanisms of thrombosis susceptibility website
Lauren Weiss, PhDAssistant Professor, Psychiatry
genetics of autism website
Zena Werb, PhDProfessor, Anatomybreast development, breast cancer, epithelial biology, tumor, microenvironment, tumor metastasis website
Paul J. Wolters, MDAssistant Professor, Pulmonary and Critical Caremast cell, sepsis, pneumonia, IL-6, protease, fibrosis, matrix, remodeling, epithelial to mesenchymal transition, translational, research, Th2 cytokine website
Keith R. Yamamoto, PhD
Professor, Cellular and Molecular Pharmacologymouse models of human neurogenetic disease, neuronal migration defects, neurogenesis, neural tube closure, social behavior, autism website
Yerem Yeghiazarians, MD
Assistant Professor, Medicinestem cell (adult and embryonic), myocardial infarction, myocardial repair, vascular biology, basic, translational and clinical research website
Midori Yenari, MDAssociate Professor, Neurologystroke, cerebral ischemia, inflammation, microglia, stress proteins website
William L. Young, PhD
Professor, Anesthesia, Neurosurgery and Neurologyneuroanesthesia, intracranial hemorrhage, brain arteriovenous malformations, intracranial aneurysm, cerebral hemodynamics website
Ann Zovein, PhD
Assistant Professor , CVRI
Vascular contributions to hematopoiesis, and other unique properties of endothelium website